Jnk1 regulate jun protein turnover9/28/2023 The overexpression of c-Jun has been observed in many types of carcinomas, including nasopharyngeal carcinomas (NPC), solid squamous cell carcinomas (SCC), glioblastoma, and other cancer types. C-Jun plays essential roles in a variety of cellular processes, ranging from cell proliferation and differentiation to tumorigenesis and cellular apoptosis. Our findings not only reveal a new mechanism regulating c-Jun activation, but also identify the NSL complex as a c-Jun co-activator in c-Jun-regulated gene expression, expanding our knowledge of the function of the NSL complex in gene expression regulation.Ĭ-Jun, the major AP-1 transcription factor family member, is activated by a broad range of extracellular signals, including growth factors, cytokines and extracellular stresses. More interestingly, we also found that the NSL complex promotes the release of the repressive NuRD complex from c-Jun target genes, thus activating c-Jun. The NSL complex catalyzes H4K16 acetylation at c-Jun target genes, thereby promoting c-Jun target gene transcription. Here we present evidence showing that c-Jun recruits the NSL complex to c-Jun target genes upon activation. However, the biological function of the NSL complex is largely unknown. The males absent on the first (MOF)-containing non-specific lethal (NSL) complex has been shown to positively regulate gene expression. Enormous efforts have been made to understand the mechanisms regulating c-Jun activation. The proto-oncogene c-Jun plays essential roles in various cellular processes, including cell proliferation, cell differentiation, and cellular apoptosis. Received: MaAccepted: ApPublished: Abstract Keywords: C-Jun NSL complex H4K16 acetylation NuRD complex phosphorylation Yan Liu 1, Yuehong Long 1, Zhaobin Xing 1 and Daoyong Zhang 2ġ College of Life Sciences, Hebei United University, Tangshan, ChinaĢ Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |